Description

(2S, 2’S)-6-Fluoro-2-(2’-Oxiranyl)Chromane CAS NO 129050-23-3 is a high-purity chiral building block featuring a fused chromane and oxirane (epoxide) ring system. This compound is of significant value in advanced pharmaceutical synthesis, serving as a key intermediate for constructing complex molecules with precise stereochemistry. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries developing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated and oxygenated heterocycles.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, especially in central nervous system (CNS) and cardiovascular research.
• Asymmetric Synthesis: Used in stereoselective reactions to introduce the chromane-oxirane scaffold into target molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the bioactivity of fluorinated chromane derivatives.
• Fine Chemical Production: Serves as a precursor for manufacturing specialized agrochemicals and performance materials requiring this specific fluorinated architecture.
• Process Chemistry Development: Utilized in scaling up synthetic routes for APIs where this intermediate is pivotal for yield and purity.

Basic Information

Product Name	(2S, 2’S)-6-Fluoro-2-(2’-Oxiranyl)Chromane
CAS No.	129050-23-3
Molecular Formula	C13H13FO3
Molecular Weight	236.24 g/mol
Synonyms	6-Fluoro-2-(2-oxiranyl)-2H-chromane, (2S,2'S)-; (2S,2'S)-6-Fluoro-2-(2'-oxiranyl)-2H-1-benzopyran; 2H-1-Benzopyran, 6-fluoro-2-(2-oxiranyl)-, (2S,2'S)-; 129050-23-3; (2S,2'S)-6-Fluoro-2-(oxiran-2-yl)chroman; Fluoro-oxiranylchromane enantiomer; Chiral fluorinated chromane epoxide.
EINECS	Contact for details

Quality Control

Our (2S, 2’S)-6-Fluoro-2-(2’-Oxiranyl)Chromane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.