Description

4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Benzaldehyde is a highly specialized benzaldehyde derivative featuring a reactive diazirine and trifluoromethyl group, making it a critical photoaffinity labeling reagent. Its core value lies in enabling precise, covalent cross-linking studies for mapping biomolecular interactions and active sites. This compound is essential for researchers and developers in pharmaceutical discovery, proteomics, and chemical biology who require advanced tools for target identification and validation.

Application

• Photoaffinity Labeling (PAL): A key reagent for irreversible covalent bonding to biological targets upon UV light activation, used to study protein-ligand, protein-protein, and protein-nucleic acid interactions.
• Chemical Proteomics: Integral to activity-based protein profiling (ABPP) for identifying enzyme active sites and mapping functional proteomes in complex biological samples.
• Drug Discovery & Medicinal Chemistry: Used to create photo-crosslinkable probes for target identification, mechanism of action studies, and hit-to-lead optimization of novel therapeutics.
• Bioconjugation & Probe Synthesis: Serves as a versatile building block for synthesizing advanced molecular probes, biosensors, and diagnostic agents due to its reactive aldehyde and photoactivatable diazirine groups.
• Materials Science Research: Employed in surface functionalization and the development of smart polymeric materials where light-induced covalent attachment is required.

Basic Information

Product Name	4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Benzaldehyde
CAS No.	128886-88-4
Molecular Formula	C9H5F3N2O
Molecular Weight	214.15 g/mol
Synonyms	3-(4-Formylphenyl)-3-(trifluoromethyl)diazirine; 4-(3-Trifluoromethyl-3H-diazirin-3-yl)benzaldehyde; p-(3-Trifluoromethyl-3H-diazirin-3-yl)benzaldehyde; 4-(3-Trifluoromethyldiazirin-3-yl)benzaldehyde; Benzaldehyde, 4-[3-(trifluoromethyl)-3H-diazirin-3-yl]-; TPDB; Trifluoromethylphenyldiazirine Benzaldehyde; Photoaffinity Labeling Benzaldehyde Reagent
EINECS	Contact for details

Quality Control

Our production of 4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Benzaldehyde adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided to guarantee the material meets the high standards required for chemical biology and proteomics research.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as indicated on the label or COA. This compound is strictly light-sensitive and must be protected from all light exposure to maintain stability and reactivity. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.