Description

Bicyclo[1.1.1]pentane, 1-bromo- (9Ci) is a highly strained, cage-like organic compound featuring a unique bridgehead bromine atom, making it a valuable and versatile building block in advanced synthetic chemistry. This compound is prized for its role as a key precursor in the synthesis of bioisosteres, particularly for the incorporation of the bicyclo[1.1.1]pentane (BCP) motif, which is used to replace *para*-substituted benzene rings or tert-butyl groups in drug discovery to improve metabolic stability and physicochemical properties. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries seeking to develop novel compounds with enhanced profiles.

Application

• Pharmaceutical Intermediate: A critical precursor for synthesizing bicyclo[1.1.1]pentane (BCP) bioisosteres in medicinal chemistry to optimize drug candidates.
• Agrochemical Synthesis: Used in the development of novel active ingredients with improved stability and efficacy.
• Materials Science Research: Serves as a building block for creating rigid, three-dimensional structures in advanced polymers and functional materials.
• Cross-Coupling Reactions: The bromine atom facilitates various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) for carbon-carbon bond formation.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands and organocatalysts.
• Academic & R&D: A valuable reagent for methodological development and exploring new chemical space in organic synthesis.

Basic Information

Product Name	Bicyclo[1.1.1]pentane, 1-bromo- (9Ci)
CAS No.	128884-80-0
Molecular Formula	C5H7Br
Molecular Weight	147.01 g/mol
Synonyms	1-Bromobicyclo[1.1.1]pentane; Bicyclo[1.1.1]pentan-1-yl bromide; 1-Bromo-bicyclo[1.1.1]pentane; BCP-Br; (Bicyclo[1.1.1]pentan-1-yl)bromide; 1-BCP-Br; Bromobicyclo[1.1.1]pentane
EINECS	Contact for details

Quality Control

Our Bicyclo[1.1.1]pentane, 1-bromo- is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature, handling and storage should minimize exposure to light.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95% (Typical: 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.