Description

(E)-4-Amino-4-Ethoxy-1,1,1-Trifluorobut-3-En-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethylated enone structure. This compound is critical for the synthesis of complex molecules, offering a versatile building block for introducing fluorine and amino functionalities. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry for creating fluorinated analogs.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the trifluoromethyl group enhances biological activity and stability.
• Fluorine Chemistry Research: Serves as a valuable reagent for academic and industrial research exploring new reactions and methodologies in organofluorine chemistry.
• Material Science: Potential precursor for specialty polymers or coatings that benefit from the properties imparted by fluorine atoms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in bespoke synthesis projects for clients.

Basic Information

Product Name	(E)-4-Amino-4-Ethoxy-1,1,1-Trifluorobut-3-En-2-One
CAS No.	128648-60-2
Molecular Formula	C6H8F3NO2
Molecular Weight	183.13 g/mol
Synonyms	4-Amino-4-ethoxy-1,1,1-trifluorobut-3-en-2-one; (E)-4-Amino-4-ethoxy-1,1,1-trifluoro-3-buten-2-one; 4-Ethoxy-4-amino-1,1,1-trifluorobut-3-en-2-one; 1,1,1-Trifluoro-4-amino-4-ethoxy-3-buten-2-one; 128648-60-2; 4-Amino-4-ethoxy-1,1,1-trifluoro-2-butanone (enol form); Ethyl 2-amino-3,3,3-trifluoroacrylate enamine; TFAA enamine derivative
EINECS	Contact for details

Quality Control

Our (E)-4-Amino-4-Ethoxy-1,1,1-Trifluorobut-3-En-2-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistent isomeric composition. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isomeric Purity (E/Z Ratio)	≥ 95:5 (E-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.