Description

2'-Nitro-4'-Trifluoromethylacetophenone is a high-purity, synthetically valuable aromatic ketone building block. This compound is a critical intermediate in the synthesis of advanced pharmaceutical ingredients and agrochemicals, prized for its trifluoromethyl and nitro functional groups which impart unique biological activity and physicochemical properties. It is primarily utilized by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethyl group.
• Material Science Research: Used in the development of advanced organic materials, including liquid crystals and polymers with specific electronic properties.
• Chemical Research & Development: Employed as a versatile substrate for organic synthesis, including nucleophilic aromatic substitution and reduction reactions.
• Dye & Pigment Intermediate: Acts as a starting material for synthesizing complex dyes and pigments due to its nitro-aromatic structure.

Basic Information

Product Name	2'-Nitro-4'-Trifluoromethylacetophenone
CAS No.	128403-22-5
Molecular Formula	C9H6F3NO3
Molecular Weight	233.15 g/mol
Synonyms	1-(2-Nitro-4-(trifluoromethyl)phenyl)ethan-1-one; 2-Nitro-α,α,α-trifluoro-p-acetophenone; 2-Nitro-4-trifluoromethylacetophenone; 4'-Trifluoromethyl-2'-nitroacetophenone; 1-[2-Nitro-4-(trifluoromethyl)phenyl]ethanone; Ethanone, 1-[2-nitro-4-(trifluoromethyl)phenyl]-; p-Trifluoromethyl-o-nitroacetophenone
EINECS	Contact for details

Quality Control

Our 2'-Nitro-4'-Trifluoromethylacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent chemical identity. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, reducing agents, and heat sources. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.