Description

(4-(2,2,2-Trifluoroethoxy)Phenyl)Methanamine is a high-purity aromatic amine building block featuring a trifluoroethoxy substituent, offering unique electronic and steric properties for advanced chemical synthesis. This compound is valued for its role as a critical intermediate in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate fluorine-containing motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides where the trifluoroethoxy group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Advanced Material Precursor: Employed in the synthesis of monomers for specialty polymers, liquid crystals, and electronic materials.
• Chemical Research & Development: A versatile building block for medicinal chemistry and process chemistry optimization in custom synthesis projects.

Basic Information

Product Name	(4-(2,2,2-Trifluoroethoxy)Phenyl)Methanamine
CAS No.	128273-59-6
Molecular Formula	C9H10F3NO
Molecular Weight	205.18 g/mol
Synonyms	1-[4-(2,2,2-Trifluoroethoxy)phenyl]methanamine; 4-(2,2,2-Trifluoroethoxy)benzylamine; p-(Trifluoroethoxy)benzylamine; 4-(Trifluoroethoxymethyl)aniline; (4-(Trifluoroethoxy)phenyl)methylamine; α-Amino-4-(2,2,2-trifluoroethoxy)toluene; Benzenemethanamine, 4-(2,2,2-trifluoroethoxy)-
EINECS	Contact for details

Quality Control

Our (4-(2,2,2-Trifluoroethoxy)Phenyl)Methanamine is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This amine compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.