Description

trans-2-Fluoro-1-Methylcyclopropanecarboxylic Acid is a high-value fluorinated cyclopropane derivative, a key building block in advanced organic synthesis. Its unique structure, featuring a fluorine atom on the strained cyclopropane ring, is crucial for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, antivirals, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances lipophilicity and biological efficacy.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or modifier for creating specialty polymers with unique thermal or chemical resistance properties.
• Fluorine Chemistry Studies: An important reagent for academic and industrial research exploring the effects of fluorination on molecular conformation and reactivity.

Basic Information

Product Name	trans-2-Fluoro-1-Methylcyclopropanecarboxylic Acid
CAS No.	128230-88-6
Molecular Formula	C5H7FO2
Molecular Weight	118.11 g/mol
Synonyms	(1R,2S)-2-Fluoro-1-methylcyclopropane-1-carboxylic Acid; (1S,2R)-2-Fluoro-1-methylcyclopropane-1-carboxylic Acid; trans-2-Fluoro-1-methyl-1-cyclopropanecarboxylic Acid; 2-Fluoro-1-methylcyclopropanecarboxylic acid, trans-; Fluoromethylcyclopropanecarboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of trans-2-Fluoro-1-Methylcyclopropanecarboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical R&D and scale-up processes. Certificates of Analysis (COA) detailing specifications such as assay (by HPLC), enantiomeric excess, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.