Description

[1,1'-Biphenyl]-4-Carboxylic Acid, 4'-(Trifluoromethyl)-, Methyl Ester is a high-value, fluorinated biphenyl derivative that serves as a critical synthetic intermediate in advanced chemical manufacturing. Its core value lies in the unique combination of a biphenyl scaffold and a trifluoromethyl group, offering enhanced lipophilicity, metabolic stability, and electronic properties to target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is utilized to build complex active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated mesogens and electron-transport materials in display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Material Science: Incorporated as a monomer or additive to create specialty polymers with tailored thermal, optical, or surface properties.
• Organic Synthesis & Catalysis: A versatile reagent in cross-coupling reactions (e.g., Suzuki, Stille) and as a ligand precursor in catalytic systems.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new fluorinated compounds and their structure-activity relationships (SAR).

Basic Information

Product Name	[1,1'-Biphenyl]-4-Carboxylic Acid, 4'-(Trifluoromethyl)-, Methyl Ester
CAS No.	127783-73-7
Molecular Formula	C15H11F3O2
Molecular Weight	280.24 g/mol
Synonyms	4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid methyl ester; Methyl 4'-(trifluoromethyl)biphenyl-4-carboxylate; 4'-(Trifluoromethyl)biphenyl-4-carboxylic Acid Methyl Ester; 4-(Trifluoromethyl)[1,1'-biphenyl]-4'-carboxylic Acid Methyl Ester; Biphenyl-4-carboxylic acid, 4'-(trifluoromethyl)-, methyl ester; 4'-Trifluoromethyl-4-biphenylcarboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our [1,1'-Biphenyl]-4-Carboxylic Acid, 4'-(Trifluoromethyl)-, Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.