Description

Cyclopropanecarboxylic Acid, 2-(Hydroxymethyl)-2-Methyl-, Methyl Ester, trans- is a specialized chiral building block featuring a cyclopropane ring, a hydroxymethyl group, and a methyl ester functionality. This unique molecular architecture makes it a valuable intermediate for synthesizing complex molecules in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for constructing novel active ingredients. The trans-configuration of the substituents is critical for achieving specific stereochemical outcomes in target compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex, three-dimensional molecular scaffolds.
• Agrochemical Synthesis: Used in the development of advanced crop protection agents, where the cyclopropane moiety can impart unique biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Material Science Research: Investigated as a monomer or additive for creating polymers with specific mechanical or optical properties derived from the strained cyclopropane ring.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring high-purity, stereodefined intermediates.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2-(Hydroxymethyl)-2-Methyl-, Methyl Ester, trans-
CAS No.	127722-17-2
Molecular Formula	C8H14O3
Molecular Weight	158.20 g/mol
Synonyms	trans-2-(Hydroxymethyl)-2-methylcyclopropanecarboxylic acid methyl ester; Methyl trans-2-(hydroxymethyl)-2-methylcyclopropanecarboxylate; (1R,2S)-rel-2-(Hydroxymethyl)-2-methylcyclopropanecarboxylic Acid Methyl Ester; trans-2-Methyl-2-(hydroxymethyl)cyclopropanecarboxylic acid methyl ester; Cyclopropanecarboxylic acid, 2-(hydroxymethyl)-2-methyl-, methyl ester, (1R,2S)-rel-
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 2-(Hydroxymethyl)-2-Methyl-, Methyl Ester, trans- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (trans-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.