Description

2-Chloro-4-Methoxybenzonitrile is a versatile aromatic nitrile derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and methoxy substituents, makes it a valuable intermediate for constructing complex molecules with specific electronic and steric properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where its benzonitrile core provides a stable scaffold for bioactive molecules.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of liquid crystal compounds for display technologies due to its rigid, polarizable structure.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and charge-transport materials.
• Dyestuff and Pigment Intermediate: Acts as a building block for synthesizing specialized dyes and pigments with enhanced lightfastness and color properties.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for creating biaryl structures.

Basic Information

Product Name	2-Chloro-4-Methoxybenzonitrile
CAS No.	127666-99-3
Molecular Formula	C8H6ClNO
Molecular Weight	167.59 g/mol
Synonyms	2-Chloro-4-methoxybenzonitrile; 4-Methoxy-2-chlorobenzonitrile; 2-Chloro-p-anisonitrile; Benzonitrile, 2-chloro-4-methoxy-; 2-Chloro-4-methoxy-phenyl cyanide
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Methoxybenzonitrile is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. We provide detailed Certificates of Analysis (COA) with every shipment, documenting identity, assay, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.