Description

1 - (2 - Bromo - 4,5 - Difluorophenyl)Ethanone is a high-purity, multi-functional organic intermediate characterized by its bromo and difluoro substitution pattern on the phenyl ring. This specific halogenated structure makes it a valuable synthon for constructing complex molecules in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working in fine chemical synthesis. The compound's reactivity profile allows for selective functionalization, enabling the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides, where the difluorophenyl moiety can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers or functional units for advanced polymers, liquid crystals, or organic electronic materials.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Product Name	1 - (2 - Bromo - 4,5 - Difluorophenyl)Ethanone
CAS No.	127371-55-5
Molecular Formula	C8H5BrF2O
Molecular Weight	235.03 g/mol
Synonyms	2'-Bromo-4',5'-difluoroacetophenone; 1-(2-Bromo-4,5-difluorophenyl)ethan-1-one; 2-Bromo-4,5-difluoroacetophenone; Ethanone, 1-(2-bromo-4,5-difluorophenyl)-; 4',5'-Difluoro-2'-bromoacetophenone; 1-Acetyl-2-bromo-4,5-difluorobenzene; (2-Bromo-4,5-difluorophenyl)methyl ketone
EINECS	Contact for details

Quality Control

Our 1 - (2 - Bromo - 4,5 - Difluorophenyl)Ethanone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high standards, such as cGMP intermediates for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.