Description

1,3-Bis(Trimethylsilyl)Urea is a versatile organosilicon reagent primarily used as a silylating agent and a dehydrating agent in organic synthesis. Its core value lies in its ability to efficiently introduce trimethylsilyl (TMS) protecting groups and activate carboxylic acids for amide bond formation. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for complex synthetic routes. CAS NO 127290-39-5.

Application

• Silylating Agent: Used to protect hydroxyl and amine groups in sensitive intermediates during multi-step synthesis.
• Peptide Coupling Reagent: Facilitates the formation of amide bonds by activating carboxylic acids, serving as an alternative to traditional carbodiimide reagents.
• Chemical Intermediate: A key building block in the synthesis of more complex organosilicon compounds and functional materials.
• Dehydrating Agent: Employed in reactions where the removal of water is critical to drive equilibrium or prevent hydrolysis.
• Pharmaceutical Synthesis: Used in the production of active pharmaceutical ingredients (APIs) requiring silyl protection strategies.
• Agrochemical Manufacturing: Applied in the synthesis of advanced crop protection agents and herbicides.

Basic Information

Product Name	1,3-Bis(Trimethylsilyl)Urea
CAS No.	127290-39-5
Molecular Formula	C7H20N2OSi2
Molecular Weight	204.42 g/mol
Synonyms	BSU; 1,3-Bis(trimethylsilyl)urea; N,N'-Bis(trimethylsilyl)urea; Urea, 1,3-bis(trimethylsilyl)-; Urea, N,N'-bis(trimethylsilyl)-; Trimethylsilyl urea derivative; TMS-urea; BTMSU
EINECS	Contact for details

Quality Control

Our 1,3-Bis(Trimethylsilyl)Urea is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and industrial applications. Each lot is analyzed to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) documenting these results are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.