Description

Clarithromycin (9Z)-Oxime is a key pharmaceutical intermediate in the synthesis of advanced macrolide antibiotics. This compound is critical for ensuring the purity and efficacy of the final active pharmaceutical ingredient (API). It is primarily required by manufacturers in the pharmaceutical and fine chemical industries engaged in the research, development, and production of antibiotic formulations.

Application

• Primary Intermediate in the synthesis of Clarithromycin and related macrolide antibiotic APIs.
• Research & Development of novel antibiotic compounds and derivative studies within pharmaceutical R&D laboratories.
• Process Chemistry for scale-up and optimization of antibiotic manufacturing routes.
• Reference Standard for analytical method development and quality control testing in API production.
• Fine Chemical Synthesis for creating specialized macrolide structures for biological evaluation.

Basic Information

Product Name	Clarithromycin (9Z)-Oxime
CAS No.	127253-05-8
Molecular Formula	C38H69NO13
Molecular Weight	747.97 g/mol
Synonyms	6-O-Methylerythromycin A 9-(Z)-Oxime; Clarithromycin 9-(Z)-Oxime; (9Z)-6-O-Methylerythromycin 9-oxime; (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione 9-oxime (Z)-isomer
EINECS	Contact for details

Quality Control

Our Clarithromycin (9Z)-Oxime is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all test results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.