Description

3-o-De(2,6-Dideoxy-3-C-Methyl-3-o-Methyl-α-L-Ribo-Hexopyranosyl)-8,9,10,11-Tetradehydro-9-Deoxo-11,12-Dideoxy-9,12-Epoxy-6-o-Methylerythromycin is a complex, semi-synthetic derivative of erythromycin, a foundational macrolide antibiotic. This compound is of significant interest in pharmaceutical research and development as a key intermediate or precursor for synthesizing novel, more potent, or targeted antibiotic agents. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions engaged in advanced antibiotic discovery and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of next-generation macrolide antibiotics with improved efficacy or spectrum of activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to understand and optimize the biological properties of erythromycin derivatives.
• API Development: Acts as a precursor in the development and scale-up processes for new active pharmaceutical ingredients (APIs) targeting bacterial infections.
• Antibiotic Resistance Research: Investigated for potential activity against drug-resistant bacterial strains, contributing to the fight against antimicrobial resistance (AMR).
• Biochemical Research: Employed as a tool compound in studies exploring bacterial protein synthesis and the mechanism of action of macrolides.

Basic Information

Product Name	3-o-De(2,6-Dideoxy-3-C-Methyl-3-o-Methyl-α-L-Ribo-Hexopyranosyl)-8,9,10,11-Tetradehydro-9-Deoxo-11,12-Dideoxy-9,12-Epoxy-6-o-Methylerythromycin
CAS No.	127157-35-1
Molecular Formula	C36H61NO11
Molecular Weight	683.87 g/mol
Synonyms	9-Deoxo-9,12-epoxy-11,12-dideoxy-6-O-methylerythromycin A; 6-O-Methyl-9-deoxo-9,12-epoxy-11,12-dideoxyerythromycin A; 9,12-Anhydro-6-O-methylerythromycin A; 9(S)-Dihydro-9-deoxo-9,12-epoxy-6-O-methylerythromycin; Erythromycin derivative 127157-35-1; 6-O-Methylerythromycin A 9,12-cyclic ether
EINECS	Contact for details

Quality Control

Our 3-o-De(2,6-Dideoxy-3-C-Methyl-3-o-Methyl-α-L-Ribo-Hexopyranosyl)-8,9,10,11-Tetradehydro-9-Deoxo-11,12-Dideoxy-9,12-Epoxy-6-o-Methylerythromycin is produced and tested under a strict quality management system. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. The material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.