Description

(S)-2-Fluoro-4-Methylpentanoic Acid CAS NO 126957-44-6 is a high-purity chiral fluorinated carboxylic acid building block, essential for introducing fluorine atoms and stereochemical control into complex molecular architectures. Its value lies in enabling the synthesis of novel, biologically active compounds with enhanced metabolic stability and binding affinity. This intermediate is critically needed by pharmaceutical and agrochemical R&D teams developing next-generation active ingredients, particularly for applications in medicinal chemistry and crop protection.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated active pharmaceutical ingredients (APIs), including potential protease inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in creating advanced fluorinated herbicides, fungicides, and insecticides where the fluorine atom improves lipophilicity and environmental stability.
• Medicinal Chemistry & Drug Discovery: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in preclinical research.
• Chiral Auxiliary & Ligand Precursor: The defined (S)-stereocenter makes it valuable for synthesizing chiral catalysts, ligands, and auxiliaries used in asymmetric synthesis.
• Fluorine-Containing Material Science: Potential use in synthesizing specialty monomers or additives for advanced polymers and functional materials.
• Academic & Contract Research: A critical reagent for universities and CROs (Contract Research Organizations) conducting cutting-edge research in synthetic organic and fluorine chemistry.

Basic Information

Product Name	(S)-2-Fluoro-4-Methylpentanoic Acid
CAS No.	126957-44-6
Molecular Formula	C6H11FO2
Molecular Weight	134.15 g/mol
Synonyms	(S)-2-Fluoro-4-methylpentanoic acid; (2S)-2-Fluoro-4-methylpentanoic acid; (S)-2-Fluoro-4-methylvaleric acid; 4-Methyl-2-fluoropentanoic acid, (S)-; L-2-Fluoro-4-methylpentanoic acid; (S)-4-Methyl-2-fluoropentanoic acid; 126957-44-6; Pentanoic acid, 2-fluoro-4-methyl-, (2S)-
EINECS	Contact for details

Quality Control

Our (S)-2-Fluoro-4-Methylpentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for research and development use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.