Description

7-Forskolinyl-2-(3-Azido-5-Hydroxy-4-Iodophenoxy)Acetate is a chemically modified derivative of forskolin, a diterpenoid compound of significant interest in biochemical research. This specialized intermediate is designed for advanced applications in medicinal chemistry and pharmaceutical development, particularly in the synthesis of targeted probes and novel drug candidates. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of adenylate cyclase modulators and other cell-signaling pathways.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel forskolin-based drug candidates targeting metabolic and cardiovascular disorders.
• Biochemical Probe Development: Used to create photoaffinity labeling agents and activity-based probes for studying adenylate cyclase and protein kinase A (PKA) signaling mechanisms.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of therapeutic compounds.
• High-Throughput Screening (HTS): Employed in the development of assay libraries for discovering new modulators of cyclic AMP (cAMP) pathways.
• Conjugate Synthesis: The azido and phenolic hydroxyl groups enable facile conjugation via click chemistry or esterification for creating bioconjugates and targeted delivery systems.

Basic Information

Product Name	7-Forskolinyl-2-(3-Azido-5-Hydroxy-4-Iodophenoxy)Acetate
CAS No.	126869-27-0
Molecular Formula	C27H33IN3O6
Molecular Weight	622.48 g/mol
Synonyms	7-Deacetylforskolin-7-[2-(3-azido-5-hydroxy-4-iodophenoxy)acetate]; 7-O-[2-(3-Azido-5-hydroxy-4-iodophenoxy)acetyl]forskolin; 7-Forskolinyl-2-(3-azido-5-hydroxy-4-iodophenoxy)ethanoate; 7-[(3-Azido-5-hydroxy-4-iodophenoxy)acetyl]forskolin; Forskolin azido-iodophenoxy derivative; cAMP activator azido probe; Coleonol derivative, 7-substituted
EINECS	Contact for details

Quality Control

Our 7-Forskolinyl-2-(3-Azido-5-Hydroxy-4-Iodophenoxy)Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light should be avoided to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.