Description

2-(2-(3-Chloropropyl)Cyclopropyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a pinacol boronic ester derivative, designed for advanced synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and agrochemical development. This compound is essential for researchers and process chemists in the fine chemical, pharmaceutical, and material science industries who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry programs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific cyclopropyl-containing structures.
• Material Science Research: Serves as a precursor for creating functional organic materials, including polymers and liquid crystals with tailored properties.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to introduce the functionalized cyclopropyl moiety into target molecules.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for biological target identification and validation.
• Catalyst Ligand Development: Acts as a starting material for synthesizing novel ligand frameworks used in asymmetric catalysis.

Basic Information

Product Name	2-(2-(3-Chloropropyl)Cyclopropyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	126726-63-4
Molecular Formula	C₁₄H₂₆BClO₂
Molecular Weight	272.62 g/mol
Synonyms	2-(2-(3-Chloropropyl)cyclopropyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-(3-Chloropropyl)cyclopropyl)boronic acid pinacol ester; 3-Chloropropylcyclopropylpinacolboronate; 2-[2-(3-Chloropropyl)cyclopropyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-(3-Chloropropyl)cyclopropyl)BPin; Cyclopropanepinacolboronate, 2-(3-chloropropyl)-; 126726-63-4; Pinacol (2-(3-chloropropyl)cyclopropyl)boronate
EINECS	Contact for details

Quality Control

Our 2-(2-(3-Chloropropyl)Cyclopropyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B) and HPLC analysis, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.