Description

Cyclopropanecarboxylic Acid, 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester, (1R,2R)-Rel- CAS NO 126689-05-2 is a high-value, stereochemically defined boronic ester building block. This compound is critical for enabling precise carbon-carbon bond formation in complex molecule synthesis, offering exceptional control over stereochemistry. It is primarily sought after by pharmaceutical and advanced agrochemical R&D teams for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system and metabolic diseases.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a sophisticated boronate reagent for constructing complex, stereodefined biaryl and alkyl-aryl structures under mild conditions.
• Agrochemical Synthesis: Used in the research and development of novel, stereoselective herbicides, fungicides, and insecticides.
• Material Science Research: Employed in the creation of chiral organic frameworks and advanced polymers with specific optical or electronic properties.
• Asymmetric Synthesis: Utilized as a chiral synthon in catalytic asymmetric transformations to introduce the cyclopropane moiety with high enantiomeric purity.
• Contract Research & Development (CRO/CMO): Supplied to research organizations and custom synthesis manufacturers for client-directed projects.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester, (1R,2R)-Rel-
CAS No.	126689-05-2
Molecular Formula	C11H19BO4
Molecular Weight	226.08 g/mol
Synonyms	(1R,2R)-rel-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropanecarboxylic acid methyl ester; Methyl (1R,2R)-rel-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropanecarboxylate; (1R,2R)-Methyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropanecarboxylate; trans-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropanecarboxylic acid methyl ester; Pinacol (1R,2R)-2-(Methoxycarbonyl)cyclopropylboronate; B-((1R,2R)-2-(Methoxycarbonyl)cyclopropyl)pinacolborane
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols, ensuring batch-to-batch consistency for critical R&D and scale-up work. Purity is typically verified by HPLC, GC, and NMR analysis, with chiral purity being a key specification. A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% (for specified isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.