Description

Cyclopropylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient and selective introduction of the valuable cyclopropyl moiety into complex molecular frameworks. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery, process development, and the synthesis of novel chemical entities.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent in Suzuki-Miyaura cross-coupling reactions for constructing C-C bonds to create novel drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Research & Development: Used to incorporate the cyclopropyl group into molecules for developing new herbicides, fungicides, and insecticides with enhanced biological activity.
• Material Science & OLED Development: Employed in the synthesis of organic semiconductors, liquid crystals, and light-emitting materials where the cyclopropyl unit modifies electronic properties.
• Medicinal Chemistry & Lead Optimization: Facilitates structure-activity relationship (SAR) studies by allowing precise modification of core molecular scaffolds.
• Process Chemistry & Scale-up: The pinacol ester protection enhances stability, making it suitable for large-scale manufacturing processes under industrial conditions.
• Academic & Contract Research: A staple reagent in university laboratories and CROs (Contract Research Organizations) for methodological development and exploratory synthesis.

Basic Information

Product Name	Cyclopropylboronic Acid Pinacol Ester
CAS No.	126689-01-8
Molecular Formula	C9H17BO2
Molecular Weight	168.04 g/mol
Synonyms	Cyclopropylboronic Acid Pinacol Ester; Cyclopropyl-4,4,5,5-Tetramethyl-1,3,2-dioxaborolane; 2-Cyclopropyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Cyclopropylboronic Acid, Pinacol Ester; Cyclopropyl MIDA Boronate (related precursor); CyclopropylBPin; CyclopropylBpin; CP-BPin
EINECS	Contact for details

Quality Control

Our Cyclopropylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment aligns with the standards required for cGMP and ISO 9001 environments, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis and maintain optimal purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
NMR Purity (1H NMR)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.