Description

Resorthiomycin is a bioactive thiopeptide antibiotic with potent activity against Gram-positive bacteria, including multidrug-resistant strains. It serves as a critical research tool in antimicrobial mechanism studies, resistance profiling, and novel antibiotic development pipelines. Pharmaceutical R&D laboratories, academic research institutions, and contract research organizations (CROs) rely on high-purity Resorthiomycin CAS NO 126651-92-1 for target validation, mode-of-action assays, and preclinical candidate screening.

Application

• Antibiotic resistance mechanism studies in Staphylococcus aureus and Enterococcus faecium
• Target engagement assays for ribosomal protein L11 and 23S rRNA binding
• Lead optimization support in thiopeptide-based drug discovery programs
• In vitro microbiological potency testing (MIC/MBC determination)
• Reference standard for HPLC and LC-MS/MS method development and validation
• Cell-based cytotoxicity and selectivity profiling in mammalian cell lines
• Crystallization trials for structural biology (X-ray crystallography, cryo-EM)
• Quality control reference material for biosynthetic pathway engineering in actinomycete fermentation

Basic Information

Product Name	Resorthiomycin
CAS No.	126651-92-1
Molecular Formula	C67H72N16O15S6
Molecular Weight	1581.74 g/mol
Synonyms	Resorthiomycin; NSC 654372; RP 71955; Thiostrepton analog B; [3-Methylindolic acid]-containing thiopeptide; Antibiotic X-126651; Thiopeptide S-126; L-654,372
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are tested per ICH Q5 and Q7 guidelines for biotechnological products, with full traceability from fermentation source to purified final substance. Testing includes identity confirmation (HPLC co-injection with reference standard, HRMS), assay (HPLC-UV), related substances (HPLC gradient), residual solvents (GC), heavy metals (ICP-MS), and microbial limits (USP & Ph. Eur. methods). Products meet or exceed ACS Reagent Grade specifications for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) to prevent oxidation and degradation. Due to its hygroscopic nature, maintain low humidity conditions (<30% RH) and minimize exposure to ambient air during handling.

Specification

Item	Specification
Appearance	Off-white to pale yellow lyophilized powder
Identification (HPLC)	Retention time matches reference standard (±0.2 min)
Identification (HRMS)	[M+H]+ m/z 1582.7421 ± 0.005 (calcd. for C67H73N16O15S6)
Assay (HPLC-UV)	≥95.0%
Related Substances	Single impurity ≤1.0%; Total impurities ≤3.0%
Residual Solvents (Acetonitrile, Methanol)	≤500 ppm each
Water (KF)	≤5.0%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.