Description

Pleuromulin is a naturally occurring diterpene antibiotic with a unique pleuromutilin core structure. This compound is of significant commercial and research interest due to its potent antibacterial activity, particularly against Gram-positive pathogens. It serves as the foundational scaffold for the development of modern semi-synthetic antibiotics used in human and veterinary medicine. Key industries requiring this high-purity intermediate include pharmaceutical R&D, animal health, and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Primary use as the key starting material for the synthesis of advanced pleuromutilin antibiotics like retapamulin (topical) and lefamulin (systemic).
• Veterinary Medicine Development: Research and production of antimicrobials for treating bacterial infections in livestock and companion animals.
• Microbiological Research: Used as a reference standard and tool compound to study bacterial protein synthesis and mechanisms of antibiotic action.
• Fine Chemical Synthesis: Valuable chiral building block for organic chemists exploring novel diterpene derivatives with biological activity.
• Antibiotic Resistance Studies: Employed in research to understand and combat emerging bacterial resistance to existing drug classes.

Basic Information

Product Name	Pleuromulin
CAS No.	125-65-5
Molecular Formula	C22H34O5
Molecular Weight	378.51 g/mol
Synonyms	Pleuromutilin; Dihydropleuromutilin; (1S,2R,3S,4S,6R,7R,8R,14S)-4-Hydroxy-2,4,7,14-tetramethyl-9-oxotricyclo[5.4.3.01,8]tetradec-11-en-6-yl acetate; Antibiotic M 4209; Antibiotic SB 22484; NSC 169425; Tiamutilin precursor
EINECS	204-751-8

Quality Control

Our Pleuromulin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data to support its use in regulated environments. A detailed Certificate of Analysis (COA) is supplied with each batch, documenting identity, purity, and impurity profiles. Our quality commitment aligns with cGMP principles for active pharmaceutical ingredients (APIs).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.