Description

3-Chloro-3-(4-Fluorophenyl)Acrylonitrile is a versatile halogenated acrylonitrile derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents, makes it a valuable precursor for constructing complex pharmacophores and functional materials. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and anti-infectives.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique optical or electronic properties.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes and molecular tags for studying enzyme function and cellular processes.
• Liquid Crystal & OLED Materials: A precursor in the synthesis of fluorinated organic compounds used in display technologies and organic light-emitting diodes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for bespoke synthesis projects and scale-up campaigns.

Basic Information

Product Name	3-Chloro-3-(4-Fluorophenyl)Acrylonitrile
CAS No.	126417-76-3
Molecular Formula	C9H5ClFN
Molecular Weight	181.59 g/mol
Synonyms	(E)-3-Chloro-3-(4-fluorophenyl)acrylonitrile; (Z)-3-Chloro-3-(4-fluorophenyl)acrylonitrile; 3-Chloro-3-(p-fluorophenyl)acrylonitrile; 2-Chloro-2-(4-fluorophenyl)ethene-1-carbonitrile; 4-Fluoro-β-chlorocinnamonitrile; 3-Chloro-3-(4-fluorophenyl)-2-propenenitrile; NSC 405124; 3-(4-Fluorophenyl)-3-chloroacrylonitrile
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-3-(4-Fluorophenyl)Acrylonitrile is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.