Description

1-Pentanone, 2,2-Difluoro-3-Hydroxy-1-Phenyl-, (-)- (9Ci) is a chiral, fluorinated β-hydroxy ketone building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines a phenyl group, fluorine atoms, and a stereogenic center, making it a valuable precursor for creating complex, bioactive molecules. Pharmaceutical, agrochemical, and specialty chemical R&D teams need this high-purity intermediate to develop novel active ingredients, particularly in the areas of asymmetric synthesis and fluorine chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in constructing advanced intermediates for novel herbicides, fungicides, and insecticides where the fluorine atoms and stereochemistry can influence biological activity and selectivity.
• Asymmetric Catalysis Research: Serves as a sophisticated substrate or ligand precursor in the development of new catalytic systems for stereoselective carbon-carbon and carbon-heteroatom bond formations.
• Material Science Precursor: Potential building block for specialty polymers, liquid crystals, or advanced organic electronic materials where fluorination and specific chirality impart desired physical properties.
• Fluorine Chemistry Studies: An important compound for academic and industrial research focused on understanding the stereoelectronic effects of fluorine atoms in organic molecules.

Basic Information

Item	Detail
Product Name	1-Pentanone, 2,2-Difluoro-3-Hydroxy-1-Phenyl-, (-)- (9Ci)
CAS No.	126392-92-5
Molecular Formula	C11H12F2O2
Molecular Weight	214.21 g/mol
Synonyms	(-)-2,2-Difluoro-3-hydroxy-1-phenyl-1-pentanone; (3S)-2,2-Difluoro-3-hydroxy-1-phenylpentan-1-one; 2,2-Difluoro-3-hydroxy-1-phenyl-1-pentanone, (-)-; 1-Phenyl-2,2-difluoro-3-hydroxypentan-1-one; (S)-2,2-Difluoro-3-hydroxy-1-phenylpentan-1-one
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols. Each batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure high chemical and enantiomeric purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid or colorless to pale yellow liquid/oil
Identification (IR / NMR)	Conforms to structure
Purity (HPLC / GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.