Description

1-Butanone, 2,2-Difluoro-3-Hydroxy-1-Phenyl-, (-)- (9Ci) is a chiral, fluorinated ketone derivative with significant synthetic utility. This compound matters as a versatile chiral building block for the preparation of complex molecules, particularly in the pharmaceutical and agrochemical sectors where its fluorine atoms and stereochemistry are critical for bioactivity. It is primarily needed by R&D chemists and process development scientists in fine chemical synthesis, serving as a key intermediate for active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of fluorinated drug candidates, including protease inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of novel, fluorinated pesticides and herbicides where the difluoro moiety enhances metabolic stability and membrane permeability.
• Advanced Material Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers and liquid crystals with tailored optical or electronic properties.
• Asymmetric Catalysis Research: Employed as a test substrate or ligand precursor in the development of new chiral catalysts and methodologies.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research exploring the effects of fluorine substitution on chemical reactivity and physical properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules on a gram to kilogram scale.

Basic Information

Product Name	1-Butanone, 2,2-Difluoro-3-Hydroxy-1-Phenyl-, (-)- (9Ci)
CAS No.	126392-91-4
Molecular Formula	C10H10F2O2
Molecular Weight	200.18 g/mol
Synonyms	(-)-2,2-Difluoro-3-hydroxy-1-phenylbutan-1-one; (3S)-2,2-Difluoro-3-hydroxy-1-phenylbutan-1-one; (S)-2,2-Difluoro-3-hydroxy-1-phenylbutan-1-one; 1-Phenyl-2,2-difluoro-3-hydroxy-1-butanone, (-)-; 2,2-Difluoro-3-hydroxy-1-phenyl-1-butanone, (-)-; 1-Butanone, 2,2-difluoro-3-hydroxy-1-phenyl-, (3S)-; 126392-91-4
EINECS	Contact for details

Quality Control

Our 1-Butanone, 2,2-Difluoro-3-Hydroxy-1-Phenyl-, (-)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP and ISO guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light to maintain stability and purity. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.