Description

44-Homooligomycin B is a specialized macrolide compound, structurally related to the oligomycin family of antibiotics. This high-purity chemical is valued for its role as a potent and specific inhibitor of mitochondrial ATP synthase, making it a critical tool in biochemical and pharmacological research. It is primarily utilized by research institutions and pharmaceutical companies engaged in metabolic studies, cancer research, and the development of novel therapeutic agents targeting cellular energy pathways.

Application

• Biochemical Research: As a selective inhibitor of the F0F1-ATPase complex for studying mitochondrial function, oxidative phosphorylation, and cellular bioenergetics.
• Cancer Biology Studies: Investigation of tumor cell metabolism and the role of ATP synthase in cancer cell proliferation and survival.
• Pharmacology & Drug Discovery: A reference standard and tool compound in screening assays for agents that modulate mitochondrial activity or induce apoptosis.
• Microbiology Research: Study of the mechanism of action of macrolide antibiotics and their effects on microbial ATP production.
• Academic & Industrial R&D: Fundamental research in cell biology, enzymology, and metabolic disorders.

Basic Information

Product Name	44-Homooligomycin B
CAS No.	125616-18-4
Molecular Formula	C46H74O12
Molecular Weight	819.1 g/mol
Synonyms	44-Homo-oligomycin B; Homooligomycin B; Oligomycin B homologue; (3R,5S,7R,9S,11R,13S,15R,17S,19R,21S,23R,25S,27R,29S,31R,33S,35R,37S,39R,41S,43R,45S)-3,5,7,9,11,13,15,17,19,21,23,25,27,29,31,33,35,37,39,41,43,45-Docosahydroxy-46-methyl-47-oxo-48,49-dioxatetracyclo[42.4.0.02,46.04,44]nonatetracontan-50-one (IUPAC); ATP synthase inhibitor (44-homo); Research-grade Oligomycin analogue.
EINECS	Contact for details

Quality Control

Our 44-Homooligomycin B is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep the primary container in a sealed secondary container. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, ethanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.