Description

Cd437 CAS NO 125316-60-1 is a potent and selective small molecule inhibitor of cyclin-dependent kinases (CDKs), specifically targeting CDK9. This compound is a critical research tool for investigating cell cycle regulation, transcription, and apoptosis pathways. It is primarily utilized by pharmaceutical R&D teams and academic researchers in the fields of oncology, molecular biology, and medicinal chemistry for target validation and drug discovery programs.

Application

• Biochemical Research: Used as a selective inhibitor to study the specific roles of CDK9 in transcriptional elongation and cell cycle progression.
• Oncology Research: Investigated for its potential to induce apoptosis in various cancer cell lines by inhibiting RNA polymerase II-dependent transcription.
• Mechanistic Studies: A key reagent for exploring the relationship between transcription, cell cycle arrest, and programmed cell death.
• Drug Discovery & Development: Serves as a lead compound or pharmacological probe in the development of novel anti-cancer therapeutics targeting CDKs.
• Signal Transduction Analysis: Employed to dissect kinase-dependent signaling pathways in cellular models.

Basic Information

Product Name	Cd437
CAS No.	125316-60-1
Molecular Formula	C21H22O3
Molecular Weight	322.40 g/mol
Synonyms	6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid; AHPN; CD 437; ST1926; NSC 656243; RARγ agonist; Synthetic retinoid; CDK9 inhibitor
EINECS	Contact for details

Quality Control

Our Cd437 is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by comprehensive analytical data including HPLC, NMR, and MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.