Description

5-Dihydroxyboryl-2-Thiouracil is a specialized organoboron derivative of the thiouracil heterocycle, serving as a critical building block in advanced synthetic chemistry. This compound matters for its unique dual functionality, combining a boronic acid moiety with a thiocarbonyl group, enabling its use in cross-coupling reactions and as a precursor for novel pharmacophores. It is primarily needed by research institutions and pharmaceutical companies engaged in developing boron-containing drugs, agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of boron-based drug candidates, particularly for boron neutron capture therapy (BNCT) and protease inhibitors.
• Agrochemical Research: Used in developing novel herbicides and fungicides that leverage the bioactivity of the boron-thiouracil structure.
• Material Science: Building block for creating boron-doped polymers or organic electronic materials with specific optoelectronic properties.
• Cross-Coupling Reactions: Serves as a boronic acid reagent in Suzuki-Miyaura cross-coupling for constructing complex biaryl and heterobiaryl systems.
• Chemical Biology Probes: Utilized in designing activity-based probes and sensors due to its reactive boronic acid group which can bind to diols.
• Academic & R&D: Fundamental research compound for studying the chemistry and reactivity of heterocyclic boronic acids.

Basic Information

Product Name	5-Dihydroxyboryl-2-Thiouracil
CAS No.	125177-38-0
Molecular Formula	C4H5BN2O2S
Molecular Weight	155.97 g/mol
Synonyms	5-Borono-2-thiouracil; 2-Thio-5-uracilboronic acid; 5-Dihydroxyboryl-2-mercaptopyrimidin-4(1H)-one; 5-Boronothiouracil; 2-Mercapto-5-pyrimidineboronic acid; 4-Hydroxy-2-mercapto-5-pyrimidineboronic acid; (4-Hydroxy-2-mercapto-5-pyrimidinyl)boronic acid
EINECS	Contact for details

Quality Control

Our 5-Dihydroxyboryl-2-Thiouracil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a desiccated environment to prevent moisture absorption and decomposition. Handle and store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.