Description

Mpeg-Cho CAS NO 125061-88-3 is a functionalized polyethylene glycol derivative featuring a reactive aldehyde (CHO) group, making it a crucial intermediate for bioconjugation and polymer chemistry. Its primary value lies in enabling the site-specific modification of peptides, proteins, and other biomolecules, which is essential for creating advanced drug delivery systems and diagnostic agents. This compound is particularly needed by researchers and manufacturers in the pharmaceutical, biotechnology, and materials science sectors for developing PEGylated therapeutics, hydrogels, and functionalized surfaces.

Application

• Pharmaceutical PEGylation: A key reagent for the covalent attachment of polyethylene glycol (PEG) chains to therapeutic proteins and peptides to enhance solubility, stability, and circulation half-life.
• Bioconjugation Linker: Used to create stable linkages between drugs, targeting ligands, and imaging agents via reaction with amine groups, forming Schiff bases that can be reduced.
• Hydrogel Synthesis: Serves as a cross-linking agent in the preparation of biocompatible hydrogels for tissue engineering and controlled drug release applications.
• Surface Functionalization: Employed to modify the surface of nanoparticles, microspheres, and medical devices with aldehyde groups for subsequent biomolecule immobilization.
• Diagnostic Reagent Production: Utilized in the development of enzyme conjugates and labeled antibodies for immunoassays and biosensors.
• Polymer Chemistry Intermediate: Acts as a macroinitiator or functional monomer in the synthesis of block copolymers and other advanced polymeric materials with tailored properties.

Basic Information

Product Name	Mpeg-Cho
CAS No.	125061-88-3
Molecular Formula	CnH2n+2O(n/2)+1 (n varies with PEG chain length)
Molecular Weight	Variable (typically 350 - 5000 g/mol). Contact for details on specific grades.
Synonyms	mPEG-CHO; Methoxy PEG aldehyde; Poly(ethylene glycol) methyl ether aldehyde; α-Methoxy-ω-aldehyde-poly(ethylene glycol); Aldehyde-PEG-OMe; PEG-CHO; O-(2-Aldehydoethyl) O'-methylpolyethylene glycol; Polyoxyethylene monomethyl ether aldehyde
EINECS	Contact for details.

Quality Control

Our Mpeg-Cho is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive bioconjugation applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity, degree of functionalization, molecular weight distribution, and residual solvent content. We adhere to cGMP guidelines where applicable to support our clients in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C for long-term stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (Aldehyde Content)	≥ 95% (by titration or NMR)
PEG Molecular Weight (Mn)	As per ordered grade (e.g., 350, 550, 750, 2000, 5000 Da)
Polydispersity Index (PDI)	≤ 1.05 (for defined grades)
Water Content (KF)	≤ 1.0%
Residual Solvent (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.