Description

2-Amino-5,7-Bis(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine is a high-value, multi-fluorinated heterocyclic building block critical for advanced material and pharmaceutical research. Its unique structure, featuring a fused triazolopyrimidine core with electron-withdrawing trifluoromethyl groups, enables the fine-tuning of electronic properties, lipophilicity, and metabolic stability in target molecules. This compound is essential for R&D chemists and process developers in the agrochemical and pharmaceutical industries seeking to incorporate sophisticated fluorinated motifs into new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-infectives, where the fluorinated scaffold can enhance bioavailability and binding affinity.
• Agrochemical Active Ingredient Synthesis: Used in developing next-generation herbicides, fungicides, and insecticides, where the triazolopyrimidine core contributes to improved pest selectivity and environmental persistence.
• Material Science Research: Acts as a building block for creating specialty polymers, liquid crystals, and organic electronic materials (e.g., OLEDs) due to its ability to modify electron transport and thermal stability.
• Chemical Biology & Probe Development: Employed in designing fluorescent tags, enzyme inhibitors, and molecular probes for diagnostic and biochemical research applications.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical suppliers and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	2-Amino-5,7-Bis(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine
CAS No.	124961-84-8
Molecular Formula	C8H3F6N5
Molecular Weight	283.14 g/mol
Synonyms	2-Amino-5,7-bis(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidine; 5,7-Bis(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine; 2-Amino-5,7-bis(trifluoromethyl)-1,2,4-triazolo[1,5-a]pyrimidine; [1,2,4]Triazolo[1,5-a]pyrimidine, 2-amino-5,7-bis(trifluoromethyl)-; 124961-84-8; 2-Amino-5,7-di(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-5,7-Bis(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical R&D and scale-up processes. Certificates of Analysis (COA) detailing specifications such as HPLC purity, NMR confirmation, and residual solvent levels are available upon request and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.