Description

n-Boc-2,2,6,6-Tetramethylpiperidine-n-Oxyl-4-Amino-4-Carboxylic Acid is a specialized, high-purity nitroxide spin label reagent used in advanced research and synthesis. This compound is critical for applications requiring stable free radicals, such as in Electron Paramagnetic Resonance (EPR) spectroscopy and as a building block for site-directed spin labeling (SDSL). It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotech, and advanced materials sectors for probing protein dynamics, studying molecular interactions, and developing functional polymers.

Application

• Site-Directed Spin Labeling (SDSL): A key precursor for covalently attaching nitroxide spin labels to specific sites on proteins and peptides for structural biology studies.
• Electron Paramagnetic Resonance (EPR) Spectroscopy: Used as a spin probe or label to investigate molecular structure, dynamics, and distances in biological macromolecules and synthetic polymers.
• Polymer & Materials Science: Serves as a functional monomer or initiator in the synthesis of nitroxide-mediated polymerization (NMP) agents and stable radical-containing polymers.
• Pharmaceutical Research: Employed in drug discovery and development to study protein-ligand interactions, conformational changes, and membrane protein dynamics.
• Bioconjugation: The carboxylic acid and protected amino groups allow for specific conjugation strategies to biomolecules for advanced diagnostic and research applications.
• Antioxidant & Radical Scavenger Studies: Acts as a model compound or standard in research focused on understanding radical chemistry and antioxidant mechanisms.

Basic Information

Product Name	n-Boc-2,2,6,6-Tetramethylpiperidine-n-Oxyl-4-Amino-4-Carboxylic Acid
CAS No.	124843-12-5
Molecular Formula	C15H28N2O5
Molecular Weight	316.40 g/mol
Synonyms	4-((tert-Butoxycarbonyl)amino)-2,2,6,6-tetramethylpiperidine-1-oxyl-4-carboxylic acid; 4-Amino-4-carboxy-TEMPO-Boc; Boc-Amino-TEMPO-COOH; 4-(Boc-amino)-2,2,6,6-tetramethylpiperidine-1-oxyl-4-carboxylic acid; 4-AT-Boc; TEMPO amino acid Boc derivative; 4-Carboxy-2,2,6,6-tetramethylpiperidine-1-oxyl-4-yl-carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-2,2,6,6-Tetramethylpiperidine-n-Oxyl-4-Amino-4-Carboxylic Acid is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical and advanced research customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (EPR)	≥ 95.0% radical content
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.