Description

16-Hydroxyclarithromycin is a key intermediate and metabolite in the synthesis and metabolic pathway of the macrolide antibiotic clarithromycin. This compound is of significant interest for pharmaceutical research and development, particularly in the study of antibiotic efficacy, metabolism, and the creation of novel derivatives. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical suppliers engaged in advanced antibiotic development and analytical method validation.

Application

• Pharmaceutical Intermediate: Critical starting material or intermediate in the synthesis of clarithromycin and its related analogs.
• Metabolite Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for pharmacokinetic and bioequivalence studies.
• Biochemical Research: Employed in studies investigating the mechanism of action, resistance, and metabolic pathways of macrolide antibiotics.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the development of new antibiotic formulations and drug delivery systems.
• Quality Control & Assurance: Essential for developing and validating HPLC, LC-MS, and other analytical methods for impurity profiling and assay determination.

Basic Information

Product Name	16-Hydroxyclarithromycin
CAS No.	124412-58-4
Molecular Formula	C38H69NO14
Molecular Weight	763.97 g/mol
Synonyms	6-O-Methyl-11,12-dideoxy-3-O-(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)-12,11-(oxycarbonyl-(4-(4-(3-hydroxy-2,4,6-trimethyl-5-oxoheptyl)-3,5-dimethyl-1H-pyrrol-2-yl)-3-hydroxy-2,4,6-trimethyl-5-oxoheptyl)imino)-5-O-(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)erythronolide; Clarithromycin, 14-hydroxy-; 14-Hydroxyclarithromycin; 16-Hydroxy-6-O-methylerythromycin A
EINECS	Contact for details

Quality Control

Our 16-Hydroxyclarithromycin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and MS, to ensure it meets high-purity standards suitable for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.