Description

2,2,2,2'-Tetrafluoroacetophenone is a specialized fluorinated aromatic ketone, a key building block in advanced organic synthesis. Its value lies in the unique reactivity and electronic properties imparted by the tetrafluoroacetone moiety, which is critical for developing novel compounds with enhanced stability and performance. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, particularly for creating active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of fluorinated drug candidates, where the fluorine atoms can improve metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used to develop advanced pesticides and herbicides, leveraging fluorine's ability to enhance lipophilicity and environmental persistence of active ingredients.
• Liquid Crystal & OLED Materials: Serves as a key fluorinated building block for electronic materials, contributing to improved dielectric anisotropy and thermal stability in display technologies.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart unique surface properties, chemical resistance, and altered refractive indices.
• Advanced Organic Synthesis: Employed in cross-coupling reactions, nucleophilic additions, and as a directing group in complex multi-step syntheses for research and development.
• Fluorinated Ligand & Catalyst Development: Used to synthesize novel ligands for catalysis, where the electron-withdrawing fluoro groups fine-tune metal center reactivity.

Basic Information

Product Name	2,2,2,2'-Tetrafluoroacetophenone
CAS No.	124004-75-7
Molecular Formula	C8H4F4O
Molecular Weight	192.11 g/mol
Synonyms	2,2,2-Trifluoro-1-phenylethanone Trifluoromethyl Ketone; α,α,α-Trifluoroacetophenone (common misnomer for tetrafluoro derivative); Phenyl Trifluoromethyl Ketone; 1-Phenyl-2,2,2-trifluoroethanone; (Trifluoroacetyl)benzene; Benzoyltrifluoromethane; TFAP; TFAK
EINECS	Contact for details

Quality Control

Our 2,2,2,2'-Tetrafluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.