Description

4'',6-Di-o-Methylerythromycin CAS NO 123967-58-8 is a chemically modified derivative of the macrolide antibiotic erythromycin, specifically methylated at the 4'' and 6 hydroxyl positions of the cladinose sugar. This semi-synthetic modification is crucial for enhancing the compound's stability and altering its biological activity profile, making it a valuable intermediate in advanced pharmaceutical research and development. It is primarily utilized by R&D scientists and manufacturers in the pharmaceutical industry for the synthesis of next-generation antibiotics and for probing structure-activity relationships.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of novel, potent macrolide antibiotic derivatives.
• Antibacterial Research: Used in microbiological and pharmacological studies to investigate the impact of specific sugar moiety modifications on antibiotic potency and spectrum.
• Medicinal Chemistry: A critical building block for creating chemical libraries aimed at overcoming bacterial resistance mechanisms.
• API Development: Serves as a precursor in the development of Active Pharmaceutical Ingredients (APIs) with improved pharmacokinetic properties.
• Biochemical Tool: Employed as a standard or probe in studies of bacterial ribosome binding and inhibition.

Basic Information

Product Name	4'',6-Di-o-Methylerythromycin
CAS No.	123967-58-8
Molecular Formula	C39H71NO14
Molecular Weight	777.98 g/mol
Synonyms	4'',6-Di-O-methylerythromycin; 4'',6-Di-O-methylerythromycin A; Erythromycin 4'',6-dimethyl ether; 6-O-Methyl-4''-O-methylerythromycin; (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione
EINECS	Contact for details

Quality Control

Our 4'',6-Di-o-Methylerythromycin is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting high standards for research and pharmaceutical use. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.