Description

H-Boroproline Pinacol Hydrochloride is a specialized organoboron building block of significant interest in modern synthetic chemistry. Its value lies in its role as a protected form of a boron-containing proline derivative, enabling precise chemical modifications that are difficult to achieve with other reagents. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, peptide mimetics, and the synthesis of novel bioactive molecules.

Application

• Medicinal Chemistry & Drug Discovery: Serves as a key intermediate for the synthesis of boron-containing drug candidates, particularly in the development of protease inhibitors.
• Peptidomimetics: Used to incorporate boron into peptide backbones, creating analogs with enhanced stability, bioavailability, or novel biological activity.
• Suzuki-Miyaura Cross-Coupling: Acts as a sophisticated boronic ester reagent for palladium-catalyzed carbon-carbon bond formation in complex molecule assembly.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes for studying enzyme function and mechanism.
• Agrochemical Research: Utilized as a building block for novel crop protection agents with unique modes of action.
• Academic & Industrial R&D: A valuable tool for methodological development in organoboron chemistry and asymmetric synthesis.

Basic Information

Product Name	H-Boroproline Pinacol Hydrochloride
CAS No.	123948-28-7
Molecular Formula	C11H20BClNO3
Molecular Weight	259.54 g/mol
Synonyms	L-Boroproline Pinacol Ester Hydrochloride; (S)-1-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-pyrrolidine-2-carboxylic Acid Hydrochloride; H-BoroPro-OH(Pin) HCl; Boron-L-Proline Pinacol Ester Hydrochloride; Prolineboronic Acid Pinacol Ester Hydrochloride; (2S)-1-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolidine-2-carboxylic Acid Hydrochloride
EINECS	Contact for details

Quality Control

Our H-Boroproline Pinacol Hydrochloride is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) when opened to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.