Description

4'-Bromo-2',5'-Difluoroacetophenone is a high-purity, multi-functional aromatic ketone building block, distinguished by its strategic halogen and fluorine substitution pattern. This compound is critical for facilitating advanced molecular synthesis, offering precise reactivity for the introduction of complex aryl groups. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for constructing complex aryl ketone cores in bioactive molecules.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoro and bromo substituents confer specific biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for the synthesis of specialized ligands, organic semiconductors, and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine atom.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Organic Synthesis Building Block: Utilized in academic and industrial R&D for constructing complex organic architectures via nucleophilic substitution or further functionalization of the ketone group.

Basic Information

Product Name	4'-Bromo-2',5'-Difluoroacetophenone
CAS No.	123942-11-0
Molecular Formula	C8H5BrF2O
Molecular Weight	235.03 g/mol
Synonyms	1-(4-Bromo-2,5-difluorophenyl)ethanone; 4'-Bromo-2',5'-difluoroacetophenone; 2',5'-Difluoro-4'-bromoacetophenone; 4-Bromo-2,5-difluoroacetophenone; 1-(4-Bromo-2,5-difluorophenyl)ethan-1-one; Ethanone, 1-(4-bromo-2,5-difluorophenyl)-; Acetophenone, 4'-bromo-2',5'-difluoro-
EINECS	Contact for details

Quality Control

Our 4'-Bromo-2',5'-Difluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.