Description

.Alpha.-D-Ribo-Hexopyranoside, Methyl 3-Deoxy-6-o-(1,1-Dimethylethyl)Dimethylsilyl-4-o-(2-Fluorophenyl)Methyl-2-o-Methyl- is a sophisticated, multi-protected carbohydrate derivative, specifically designed as a critical advanced synthetic intermediate in complex organic synthesis. Its value lies in its precisely engineered structure, which incorporates orthogonal protecting groups (TBDMS and 2-fluorobenzyl) to enable selective deprotection and controlled reactivity in multi-step sequences. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries who require high-purity, specialized building blocks for the development of novel therapeutics, including nucleoside analogs and complex glycoconjugates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside or carbohydrate-based active pharmaceutical ingredients (APIs), particularly for antiviral or anticancer agents.
• Glycochemistry Research: Serves as a protected glycosyl donor or acceptor in the study and synthesis of complex oligosaccharides and glycoconjugates.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to explore the impact of specific sugar modifications on drug potency and selectivity.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for complex molecules in pilot plant and commercial manufacturing.
• Bioconjugation: Potential use in creating chemically defined linkers for antibody-drug conjugates (ADCs) or other targeted delivery systems.
• Fine Chemical Synthesis: Acts as a chiral precursor for the production of high-value specialty chemicals and catalysts.

Basic Information

Item	Details
Product Name	.Alpha.-D-Ribo-Hexopyranoside, Methyl 3-Deoxy-6-o-(1,1-Dimethylethyl)Dimethylsilyl-4-o-(2-Fluorophenyl)Methyl-2-o-Methyl-
CAS No.	123920-50-3
Molecular Formula	C23H39FO5Si
Molecular Weight	442.64 g/mol
Synonyms	Methyl 3-Deoxy-6-O-(tert-butyldimethylsilyl)-4-O-(2-fluorobenzyl)-2-O-methyl-α-D-ribo-hexopyranoside; Methyl 3-deoxy-6-O-[(1,1-dimethylethyl)dimethylsilyl]-4-O-[(2-fluorophenyl)methyl]-2-O-methyl-α-D-ribo-hexopyranoside; α-D-ribo-Hexopyranoside derivative; TBDMS-protected fluorobenzyl glycoside; Protected methyl glycoside intermediate
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems. We employ rigorous analytical techniques, including HPLC, NMR (1H & 13C), and mass spectrometry, to ensure identity, purity, and consistency. Our commitment to quality ensures the material meets the exacting standards required for pharmaceutical R&D and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and analytical data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.