Description

trans-3-(Trifluoromethyl)Cyclobutane-1-Carboxylic Acid CAS NO 123812-83-9 is a high-value, synthetically versatile cyclobutane derivative featuring a carboxylic acid group and a trifluoromethyl substituent. This compound is a critical building block in advanced organic synthesis, prized for its ability to introduce conformational rigidity and fluorinated motifs into target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

This specialized carboxylic acid serves as a key intermediate in sophisticated chemical synthesis. Its primary applications include:

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, metabolic diseases, and oncology.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the cyclobutane and trifluoromethyl groups enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Employed in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis, leveraging the rigid cyclobutane scaffold.
• Material Science Precursor: Acts as a monomer or functionalization agent for creating specialty polymers and advanced materials with unique thermal or surface properties.
• Fluorine Chemistry Research: An important substrate for studying structure-activity relationships (SAR) and metabolic stability in fluorinated compounds.

Basic Information

Product Name	trans-3-(Trifluoromethyl)Cyclobutane-1-Carboxylic Acid
CAS No.	123812-83-9
Molecular Formula	C6H7F3O2
Molecular Weight	168.11 g/mol
Synonyms	trans-3-(Trifluoromethyl)cyclobutanecarboxylic acid; (1r,3r)-3-(Trifluoromethyl)cyclobutanecarboxylic acid; rel-(1R,3R)-3-(Trifluoromethyl)cyclobutanecarboxylic Acid; 3-(Trifluoromethyl)cyclobutanecarboxylic acid, trans-; Cyclobutanecarboxylic acid, 3-(trifluoromethyl)-, trans-; (1R,3R)-3-(Trifluoromethyl)cyclobutan-1-carboxylic acid; (1S,3S)-3-(Trifluoromethyl)cyclobutanecarboxylic acid
EINECS	Contact for details

Quality Control

Our production of trans-3-(Trifluoromethyl)Cyclobutane-1-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for research and commercial-scale supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.