Description

cis-3-(Trifluoromethyl)Cyclobutane-1-Carboxylic Acid is a high-value, fluorinated cyclobutane building block essential for advanced organic synthesis. Its unique structure, featuring a strained cyclobutane ring and a trifluoromethyl group, makes it a critical intermediate for modulating the physicochemical properties of target molecules. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, leveraging the steric and electronic properties of the cyclobutane scaffold.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced materials where fluorinated moieties impart desired characteristics like chemical resistance or modified surface energy.
• Fluorine Chemistry Building Block: A versatile starting material for introducing the pharmacologically privileged trifluoromethyl group into complex molecular architectures.

Basic Information

Product Name	cis-3-(Trifluoromethyl)Cyclobutane-1-Carboxylic Acid
CAS No.	123812-82-8
Molecular Formula	C6H7F3O2
Molecular Weight	168.11 g/mol
Synonyms	cis-3-(Trifluoromethyl)cyclobutanecarboxylic acid; 3-(Trifluoromethyl)cyclobutanecarboxylic acid (cis-); Cyclobutanecarboxylic acid, 3-(trifluoromethyl)-, cis-; (1r,3s)-3-(Trifluoromethyl)cyclobutanecarboxylic acid; (1s,3r)-3-(Trifluoromethyl)cyclobutanecarboxylic acid; 1-Carboxy-3-(trifluoromethyl)cyclobutane (cis-); cis-3-(Trifluoromethyl)-1-cyclobutanecarboxylic acid
EINECS	Contact for details

Quality Control

Our cis-3-(Trifluoromethyl)Cyclobutane-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.