Description

trans-3-Fluorocyclobutane-1-Carboxylic Acid is a high-value, synthetically versatile fluorinated building block. Its unique structure, featuring a carboxylic acid group on a fluorinated cyclobutane ring, makes it a critical intermediate for introducing conformational rigidity and fluorine atoms into target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to modulate the physicochemical and biological properties of new chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, metabolic diseases, and oncology.
• Agrochemical Research: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atom and rigid cyclobutane core can enhance bioavailability and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts in asymmetric synthesis, leveraging the stereochemistry of the trans-configured ring.
• Material Science Precursor: Employed in the synthesis of fluorinated polymers and advanced materials with tailored surface properties and chemical resistance.
• PET (Positron Emission Tomography) Tracer Synthesis: Potential use as a precursor for 18F-labeled diagnostic imaging agents due to the presence of a fluorine atom.
• Chemical Biology Probe: Useful for incorporating a stable, fluorinated motif into peptides or small molecules to study protein-ligand interactions and metabolic pathways.

Basic Information

Product Name	trans-3-Fluorocyclobutane-1-Carboxylic Acid
CAS No.	123812-79-3
Molecular Formula	C5H7FO2
Molecular Weight	118.11 g/mol
Synonyms	(1r,3r)-3-Fluorocyclobutane-1-carboxylic Acid; trans-3-Fluorocyclobutanecarboxylic Acid; rel-(1R,3R)-3-Fluorocyclobutane-1-carboxylic Acid; 3-Fluorocyclobutane-1-carboxylic Acid (trans); Fluorocyclobutanecarboxylic Acid; FCBCA; Fluorinated Cyclobutane Carboxylic Acid; 3-Fluoro-1-cyclobutanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our trans-3-Fluorocyclobutane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. Due to its acidic nature, handle with appropriate personal protective equipment in a fume hood.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (Titration)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.