Description

Aescin Ia(Sh) is a highly purified, specific saponin compound isolated from horse chestnut (*Aesculus hippocastanum*). This active pharmaceutical ingredient (API) is valued for its potent venotonic and anti-inflammatory properties, making it a critical component in advanced pharmaceutical formulations. It is primarily utilized by manufacturers in the pharmaceutical and nutraceutical industries for developing treatments targeting chronic venous insufficiency, edema, and related vascular conditions.

Application

• Pharmaceutical API: Core active ingredient in prescription and OTC medications for chronic venous insufficiency (CVI) and varicose veins.
• Topical Formulations: Used in creams, gels, and ointments for the relief of swelling, heaviness, and discomfort in the legs.
• Nutraceutical Supplements: Incorporated into dietary supplements aimed at supporting vascular health and circulation.
• Cosmeceutical Products: Found in skincare products designed to reduce under-eye puffiness, dark circles, and localized edema.
• Veterinary Medicine: Applied in formulations for treating similar vascular and inflammatory conditions in animals.
• Research & Development: Serves as a reference standard and key molecule in pharmacological and phytochemical research.

Basic Information

Product Name	Aescin Ia(Sh)
CAS No.	123748-68-5
Molecular Formula	C55H86O24
Molecular Weight	1131.26 g/mol
Synonyms	Aescin Ia; Aescin Ia (Sh); Escin Ia; Escin Ia (Sh); Aesculus saponin Ia; β-Aescin; (3β,16α,21β,22α)-21,22-Di(acetyloxy)-16,28-dihydroxyolean-12-en-3-yl 6-deoxy-4-O-β-D-glucopyranosyl-α-L-galactopyranoside
EINECS	Contact for details

Quality Control

Our Aescin Ia(Sh) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications suitable for pharmaceutical use. Certificates of Analysis (COA) are provided with every shipment, detailing all test results against established release criteria.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.