Description

1,3-Diiodo-5-Fluorobenzene is a high-purity, multi-functional halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both iodine and fluorine substituents, makes it a critical precursor for constructing complex molecules in pharmaceutical and materials science research. This compound is primarily sought after by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty agrochemicals.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions to introduce the diiodo-fluorophenyl moiety.
• Liquid Crystal & OLED Material Synthesis: Used as a core starting material for creating fluorinated and iodinated aromatic units that impart specific electronic and optical properties to advanced display and lighting materials.
• Agrochemical Research: Acts as a versatile intermediate in the development of new-generation herbicides, fungicides, and plant growth regulators that require halogenated aromatic systems.
• Ligand & Catalyst Preparation: Employed in the preparation of specialized ligands for metal catalysis, where the electron-withdrawing halogen groups tune the metal center's reactivity.
• Chemical Biology & Probe Development: Useful for synthesizing molecular probes and tags, leveraging the reactivity of iodine for further functionalization or conjugation.
• Polymer & Advanced Material Science: Incorporated as a monomer or modifier to produce polymers with unique thermal stability, refractive index, or chemical resistance properties.

Basic Information

Product Name	1,3-Diiodo-5-Fluorobenzene
CAS No.	123629-53-8
Molecular Formula	C6H3F1I2
Molecular Weight	363.89 g/mol
Synonyms	5-Fluoro-1,3-diiodobenzene; 1-Fluoro-3,5-diiodobenzene; 3,5-Diiodofluorobenzene; Benzene, 1,3-diiodo-5-fluoro-; 3-Fluoro-1,5-diiodobenzene; 1,3-Diiodo-5-fluorobenzol; 5-Fluororesorcinol diiodide (derivative)
EINECS	Contact for details

Quality Control

Our 1,3-Diiodo-5-Fluorobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support customer-specific analytical requirements and can provide material tailored to your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.