Description

3',5'-Difluoroacetophenone is a high-purity fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its unique difluoro substitution pattern makes it a critical intermediate for creating complex molecules with tailored electronic and steric properties. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Advanced Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine into polymer backbones, improving chemical resistance and thermal stability.
• Chemical Research & Development: A versatile building block in academic and industrial R&D for exploring new fluorination methodologies and creating specialized chemical libraries.
• Coordination Chemistry Ligand: The carbonyl and aryl fluoride groups can act as binding sites for metals, useful in catalyst design and material science.

Basic Information

Product Name	3',5'-Difluoroacetophenone
CAS No.	123577-99-1
Molecular Formula	C8H6F2O
Molecular Weight	156.13 g/mol
Synonyms	1-(3,5-Difluorophenyl)ethanone; 3,5-Difluoroacetophenone; 3,5-Difluorophenyl methyl ketone; m,m-Difluoroacetophenone; Ethanone, 1-(3,5-difluorophenyl)-; 3,5-DFAP; 3,5-Difluoroacetylbenzene; 3,5-Difluorophenacyl
EINECS	Contact for details

Quality Control

Our 3',5'-Difluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP and ISO standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	40 - 44 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.