Description

Cyclopropanecarboxaldehyde, 1-(1,2,3-Trihydroxypropyl)-, [R-(R*,S*)]- (9Ci) is a specialized chiral aldehyde derivative of cyclopropane with a glycerol-like side chain. This compound matters as a high-value chemical building block for the synthesis of complex, stereochemically defined molecules, particularly in advanced pharmaceutical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for creating novel active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new therapeutic agents, including antiviral and anticancer drugs.
• Asymmetric Synthesis: Utilized as a precursor in stereoselective reactions to construct complex molecular architectures with defined three-dimensional configurations.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing novel chiral ligands and organocatalysts used in enantioselective transformations.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic and Industrial Research: Used in chemical biology and medicinal chemistry programs to explore structure-activity relationships (SAR).
• Process Chemistry: Investigated for scale-up in the production of advanced pharmaceutical intermediates under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	Cyclopropanecarboxaldehyde, 1-(1,2,3-Trihydroxypropyl)-, [R-(R*,S*)]- (9Ci)
CAS No.	123490-28-8
Molecular Formula	C7H12O4
Molecular Weight	160.17 g/mol
Synonyms	(2R,3S)-1-Cyclopropyl-2,3-dihydroxypropan-1-one (tautomeric form); 1-Cyclopropyl-2,3-dihydroxy-1-propanone; (R*,S*)-1-(1,2,3-Trihydroxypropyl)cyclopropanecarboxaldehyde; Glyceraldehyde cyclopropane derivative; Chiral cyclopropane aldehyde triol; (2R,3S)-1-Cyclopropanecarbonylglycerol; Cyclopropanecarboxaldehyde glycerol adduct
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing specifications such as chiral purity (enantiomeric excess), chemical purity (by HPLC), and residual solvent levels are available for each lot. Our quality commitment supports development from research to commercial scale, with the potential for GMP-compliant manufacturing upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.