Description

n-Boc-(Methylamino)Acetaldehyde is a protected amino aldehyde building block of significant value in synthetic organic chemistry. Its core utility lies in providing a versatile, reactive aldehyde handle while preserving the amine functionality under a Boc (tert-butoxycarbonyl) protecting group. This compound is essential for researchers and process chemists engaged in the synthesis of complex molecules, particularly in pharmaceutical development. Its primary applications are found in the construction of heterocycles, peptide mimetics, and as a key intermediate in medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing modified amino acid structures.
• Peptidomimetic Synthesis: Used in the design and creation of peptide analogs and mimetics to improve metabolic stability and bioavailability.
• Heterocycle Formation: Serves as a key reactant in cyclization and condensation reactions to construct nitrogen-containing heterocyclic scaffolds common in many drug classes.
• Linker Chemistry: Employed in bioconjugation and the synthesis of chemical linkers for prodrugs or antibody-drug conjugates (ADCs).
• Organic Synthesis Reagent: Acts as a versatile electrophile in nucleophilic addition reactions, reductive amination, and multi-component reactions for library synthesis.
• Agrochemical Research: Utilized as an intermediate in the development of novel pesticides and herbicides that require specific chiral amine functionalities.

Basic Information

Product Name	n-Boc-(Methylamino)Acetaldehyde
CAS No.	123387-72-4
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	2-[(tert-Butoxycarbonyl)(methyl)amino]acetaldehyde; N-Boc-N-methylglycinal; N-(tert-Butoxycarbonyl)-N-methylaminoacetaldehyde; Boc-N-methyl-2-aminoacetaldehyde; (Boc-Me-amino)Acetaldehyde; N-Methyl-N-Boc-aminoacetaldehyde; 2-[(tert-Butoxycarbonyl)(methyl)amino]ethanal
EINECS	Contact for details

Quality Control

Our n-Boc-(Methylamino)Acetaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistency. We provide full traceability and a Certificate of Analysis (COA) with every shipment, detailing identity, purity, and impurity profiles. Our quality commitment supports applications requiring material of research and development (R&D) to pilot-scale grade.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.