Description

2‐(2,2‐Difluorocyclopropyl)Acetic Acid is a high-value, fluorinated cyclopropane derivative that serves as a critical building block in advanced organic synthesis. Its unique difluorocyclopropyl moiety imparts desirable metabolic stability and lipophilicity, making it a sought-after intermediate for the development of novel active compounds. This specialty chemical is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of new agrochemicals and pharmaceuticals, where precise molecular architecture is paramount.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing the metabolically stable difluorocyclopropyl group.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced materials with tailored surface properties.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Fluorine Chemistry Studies: An important compound for academic and industrial research exploring the effects of gem-difluoro substitution on cyclopropane ring strain and reactivity.

Basic Information

Product Name	2‐(2,2‐Difluorocyclopropyl)Acetic Acid
CAS No.	123131-67-9
Molecular Formula	C5H6F2O2
Molecular Weight	136.10 g/mol
Synonyms	2-(2,2-Difluorocyclopropyl)acetic Acid; Acetic Acid, 2-(2,2-Difluorocyclopropyl)-; 2,2-Difluorocyclopropaneacetic Acid; (2,2-Difluorocyclopropyl)acetic Acid; NSC 405124; 123131-67-9; 2-(2,2-Difluorocyclopropyl)ethanoic Acid
EINECS	Contact for details

Quality Control

Every batch of 2‐(2,2‐Difluorocyclopropyl)Acetic Acid is manufactured and tested under strict quality management protocols to ensure consistency and purity for sensitive synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.