Description

(2R)-4-Bromo-2-[[(tert-Butoxy)Carbonyl]Amino]Butanoic Acid tert-Butyl Ester is a high-purity, chiral building block of significant value in advanced organic synthesis. Its structure, featuring both a protected amino acid backbone and a reactive bromoalkyl handle, makes it a critical intermediate for constructing complex, stereodefined molecules. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and peptide mimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly those targeting neurological and metabolic disorders.
• Peptidomimetic Research: Serves as a protected, functionalized amino acid derivative for constructing non-natural peptide analogs with enhanced stability and bioavailability.
• Chemical Biology Probe Development: Used to introduce bromo-functionalized side chains into molecular probes for studying protein-ligand interactions and enzyme mechanisms.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to generate enantiomerically pure compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions.

Basic Information

Product Name	(2R)-4-Bromo-2-[[(tert-Butoxy)Carbonyl]Amino]Butanoic Acid tert-Butyl Ester
CAS No.	123004-74-0
Molecular Formula	C13H24BrNO4
Molecular Weight	338.24 g/mol
Synonyms	Boc-D-Homoserine(4-Br)-OtBu; (R)-4-Bromo-2-((tert-butoxycarbonyl)amino)butanoic acid tert-butyl ester; tert-Butyl (2R)-4-bromo-2-[(tert-butoxycarbonyl)amino]butanoate; Boc-D-HomoSer(Br)-OtBu; D-4-Bromo-homoserine tert-butyl ester N-Boc protected; (R)-2-(Boc-amino)-4-bromobutanoic acid tert-butyl ester; Boc-D-4-bromohomoserine-OtBu
EINECS	Contact for details

Quality Control

Our production of (2R)-4-Bromo-2-[[(tert-Butoxy)Carbonyl]Amino]Butanoic Acid tert-Butyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity, essential for sensitive pharmaceutical R&D. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.