Description

4,4-Difluorocyclohexanecarboxylic Acid is a versatile fluorinated building block of significant interest in advanced organic synthesis. Its value lies in the unique properties imparted by the difluorocyclohexyl moiety, which is crucial for modulating the lipophilicity, metabolic stability, and bioavailability of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting metabolic diseases and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the difluoro group enhances biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays.
• Advanced Polymer Modifiers: Incorporated into polymer backbones to alter physical properties such as chemical resistance, thermal stability, and dielectric constant.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, esterifications, and amide couplings to introduce a rigid, fluorinated cyclohexane carboxylic acid fragment.
• Material Science Research: Investigated for creating novel fluorinated coatings and surface modifiers with unique hydrophobic and oleophobic characteristics.

Basic Information

Product Name	4,4-Difluorocyclohexanecarboxylic Acid
CAS No.	122665-97-8
Molecular Formula	C7H10F2O2
Molecular Weight	164.15 g/mol
Synonyms	4,4-Difluorocyclohexane-1-carboxylic Acid; trans-4,4-Difluorocyclohexanecarboxylic Acid; 4,4-Difluorocyclohexylcarboxylic Acid; 4,4-Difluorocyclohexanoic Acid; 1-Carboxy-4,4-difluorocyclohexane; Cyclohexanecarboxylic acid, 4,4-difluoro-; 4,4-Difluorocyclohexane Carboxylic Acid
EINECS	Contact for details

Quality Control

Our 4,4-Difluorocyclohexanecarboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.