Description

3-Fluorocyclobutanecarboxylic Acid is a versatile fluorinated building block of significant interest in advanced organic synthesis. Its unique structure, featuring a strained cyclobutane ring and a carboxylic acid functional group, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates targeting CNS disorders, metabolic diseases, and oncology.
• Agrochemical Research: Used in the design and synthesis of new-generation herbicides, fungicides, and pesticides, where the fluorine atom can enhance bioavailability and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Precursor: Employed in the synthesis of fluorinated polymers and advanced materials with specific thermal, chemical, or surface properties.
• Chemical Biology Probe: Utilized as a building block for synthesizing fluorinated analogs of biomolecules to study metabolic pathways and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	3-Fluorocyclobutanecarboxylic Acid
CAS No.	122665-96-7
Molecular Formula	C5H7FO2
Molecular Weight	118.11 g/mol
Synonyms	3-Fluorocyclobutanecarboxylic Acid; Cyclobutanecarboxylic acid, 3-fluoro-; 3-Fluorocyclobutane-1-carboxylic acid; 3-Fluoro-1-cyclobutanecarboxylic acid; 3-Fluorocyclobutanecarboxylate; 3-Fluorocyclobutylcarboxylic Acid; 3-Fluoro-cyclobutanecarboxylic acid; 3-Fluorocyclobutanecarboxylic acid (CAS 122665-96-7)
EINECS	Contact for details

Quality Control

Our 3-Fluorocyclobutanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.