Description

D-Norvaline, 5,5,5-Trifluoro- is a high-purity, non-natural amino acid derivative distinguished by its trifluoromethyl side chain. This unique fluorinated structure is critical for enhancing the metabolic stability, lipophilicity, and binding affinity of bioactive peptides and pharmaceutical intermediates. It is an essential building block for researchers and manufacturers in advanced pharmaceutical development, agrochemical synthesis, and materials science, where precise stereochemistry and fluorine incorporation are required.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly protease inhibitors and other enzyme-targeted therapies.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate fluorinated amino acids, modifying peptide stability and membrane permeability.
• Agrochemical Research: Serves as a precursor in the design of advanced herbicides and pesticides with improved environmental and metabolic profiles.
• Biochemical Tool: Employed in metabolic pathway studies and as a substrate analog in enzymatic assays to investigate enzyme specificity and mechanism.
• Material Science: A potential monomer for creating specialized fluorinated polymers and coatings with unique surface properties.
• Diagnostic Probe Development: Utilized in the synthesis of radiolabeled or fluorescent probes for imaging and diagnostic applications.

Basic Information

Product Name	D-Norvaline, 5,5,5-Trifluoro-
CAS No.	122565-29-1
Molecular Formula	C5H8F3NO2
Molecular Weight	171.12 g/mol
Synonyms	(R)-2-Amino-5,5,5-trifluoropentanoic acid; D-5,5,5-Trifluoronorvaline; (R)-5,5,5-Trifluoronorvaline; D-2-Amino-5,5,5-trifluorovaleric acid; (2R)-2-Amino-5,5,5-trifluoropentanoic acid; D-α-Amino-5,5,5-trifluorovaleric acid; (R)-Trifluoronorvaline; D-Tfn
EINECS	Contact for details

Quality Control

Our D-Norvaline, 5,5,5-Trifluoro- is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the exacting standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.