Description

(S)-5,5,5-Trifluoronorvaline is a high-value, non-proteinogenic amino acid derivative characterized by a terminal trifluoromethyl group, offering unique steric and electronic properties. This compound is essential for modulating the pharmacokinetic and metabolic stability of bioactive molecules, making it a critical building block in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of novel peptides, enzyme inhibitors, and other fluorinated active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of fluorinated drug candidates, including protease inhibitors and enzyme-targeted therapies.
• Peptidomimetics & Medicinal Chemistry: Used to incorporate fluorine into peptide backbones to enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Research: Serves as a building block for designing novel fluorinated pesticides and herbicides with improved efficacy and environmental profiles.
• Biochemical Tool Compound: Employed in studies investigating amino acid metabolism, enzyme mechanisms, and protein engineering due to its fluorine label.
• Material Science Precursor: Potential use in the synthesis of specialized fluorinated polymers and surface-modifying agents.

Basic Information

Product Name	(S)-5,5,5-Trifluoronorvaline
CAS No.	122565-28-0
Molecular Formula	C6H10F3NO2
Molecular Weight	185.14 g/mol
Synonyms	(S)-2-Amino-5,5,5-trifluoropentanoic acid; (S)-5,5,5-Trifluoronorvaline; L-5,5,5-Trifluoronorvaline; (S)-α-Amino-5,5,5-trifluorovaleric acid; 5,5,5-Trifluoro-L-norvaline; (2S)-2-Amino-5,5,5-trifluoropentanoic acid; Norvaline, 5,5,5-trifluoro-, L-; L-5,5,5-Trifluoronorvaline
EINECS	Contact for details

Quality Control

Our (S)-5,5,5-Trifluoronorvaline is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive analytical data including HPLC purity, chiral purity, and identity confirmation. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.